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Under inflammatory conditions, ZIP14 expression is upregulated while ZNT10 is downregulated, accompanied by a three-fold increase in total Mn concentrations, suggesting that these two transporters play opposing roles in regulating Mn transport in neurons (Fujishiro et al., 2014) (Figure 2)

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Methods to measure brain aging have used MRI-based brain volume and functional connectivity measurements, which are costly and do not provide molecular insights 16 , or have required tissue samples, which prevents their application in living persons 17