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Not for individuals on MAO inhibitors, antidepressants, or psychiatric medications PEA compounds have MAO inhibitory properties and interact with antidepressants

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Cheon H, Rho YH, Choi SJ et al (2002) Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals