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Our findings demonstrated that D-lactate and DAO, serum markers of intestinal permeability [60], were significantly elevated in CLP-induced sepsis mice, suggesting severe intestinal epithelial damage, loss of mucosal integrity, and increased intestinal permeability

VEGF-A binds to both VEGFR-1 and VEGFR-2, but mainly signals through VEGFR-2 (33)

Overall, these data demonstrated that the reaction-paired metabolites in principle tend to share similar isotopologue patterns in stable-isotope tracing metabolomics