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doi: 10.1111/bph.13936

These specific metabolic vulnerabilities are not ubiquitous pan-cancer traits, but are strictly confined to tumors harboring these distinct genetic backgrounds

Keywords Viticis Fructus Phytochemistry Pharmacology Pharmacokinetics Comprehensive applications AUC (0-t) Area under the plasma concentrationtime curve Bax Bcl-2 associated X protein Bcl-2 B cell lymphoma-2 protein Bcl-xL B-cell lymphoma extra-large Bim Bcl-2 interacting mediator of cell death Caspase-3 Cysteinyl aspartate specific proteinase-3 CD Circular dichroism ChP Pharmacopoeia of the Peoples Republic of China C max Maximum drug concentration in plasma CNKI China National Knowledge Infrastructure COSY Correlation spectroscopy CRC Colorectal cancer CYR61 Cysteine-rich61 DR5 Death receptor 5 ERK Extracellular regulated protein kinases FOXM1 Forkhead box protein M1 FOXO3a Forkhead box O3 GABA -amino butyric acid GCGCMS Comprehensive two-dimensional gas chromatography hyphenated with mass spectrometry HCC Hepatocellular carcinoma HDL High-density lipoprotein HRESIMS High-resolution electrospray ionization mass spectroscopy HRFABMS High-resolution fast atom bombardment mass spectrum KOA Knee osteoarthritis LC/MS Liquid chromatography/mass spectrometry LCSLCs Lung cancer stem-like cells LDL Low density lipoprotein LD 50 median lethal dose MAPK Mitogen-activated protein kinase MMP-1 Matrix metalloproteinase-1 MMP-2 Matrix metalloproteinase-2 MMP-9 Matrix metalloproteinase-9 NF-B Nuclear factor kappa-B NIR Near Infrared NLRP3 Nucleotide oligomerization domain-like receptor protein 3 NMR Nuclear magnetic resonance NO Nitric Oxide NOESY Nuclear overhauser effect spectroscopy NPC Nasopharyngeal carcinoma PI3K/AKT Phosphatidylinositol 3-kinase/protein kinase B PKR Protein kinase R PMS Premenstrual syndrome PPY Pyranopyran-1,8-dione ROS Reactive oxygen species IL-1 Interleukin-1 IL-6 Interleukin-6 IR Infrared ray SCTF Shrub Chaste Tree Fruits TCMs Traditional Chinese medicines T max The time to reach maximum drug concentration TNF- Tumor necrosis factor- UC Ulcerative colitis HPLC-DAD High-performance liquid chromatography coupled with a diode array detector ISSR Inter simple sequence repeat ITS2 Internal transcribed spacer 2 JNK c-Jun N-terminal kinase K2P Kimura 2-Parameter UHPLC-Q-Orbitrap HRMS Ultra-high-performance-liquid chromatography-quadrupole-Orbitrap high resolution mass spectrometry UHPLC-MS Ultra-High performance liquid chromatography-mass spectrometry UV Ultraviolet

It enhances tendon, muscle, and intestinal healing in preclinical models