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Additionally, body mass index (BMI) was identified as an effect modifier, demonstrating a significant negative interaction ( = 0.021, 95% CI -0.032 to 0.010) between serum vitamin B12 and testosterone in women aged 20 to 39 years

Gonzalez- Rivas PA, Chambers M, Liu J

Nutrients for Optimisation The most important nutrients for the optimisation of the methylation cycle are: Vitamin B12 (as hydroxo- or methylcobalamin) Methylfolate (as 5-MTHF, Quatrefolic) Vitamin B6 (as pyridoxal-5-phosphate) Magnesium Nutrients for Therapy The following substances are administered for genetic mutations: Methylfolate (as 5-MTHF, Quatrefolic) Bypasses the MTHFR mutations Methionine Bypasses problems with MTHFR SAM Bypasses problems with MTHFR and MAT 5-HTP Bypasses BH4 deficiency or TPH mutations Nutrient Combinations for Certain Symptoms The following nutrient combinations are possible for certain symptoms: Nutrients for MTHFR Mutation MTHFR mutation is by far the most common genetic mutation

Store in a cool, dry place away from direct sunlight, heat and moisture