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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Soubeyrand E., Kelly M., Keene S.A., Bernert A.C., Latimer S., Johnson T.S., Elowsky C., Colquhoun T.A., Block A.K., Basset G.J

No formal clinical trial has studied this specific combination

The primary analysis was conducted using the Inverse Variance Weighted (IVW) method, and was further corroborated by an array of statistical techniques including MR-Egger, Weighted Median, Weighted Mode, cML-MA, ConMix, MR-RAPS, and DIVW to ensure robustness and reliability of the findings.Heterogeneity was evaluated using Cochrans Q test, horizontal pleiotropy was assessed through MR-Egger regression, and leave-one-out analyses were performed to validate the causal relationships

They are not an instant wrinkle eraser, and they should not be presented as a medical treatment