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Studies have demonstrated that the lifespan of mice with OC is considerably reduced owing to the continuous activity of N1ICD, which leads to the aging of endothelial cells, increased expression of chemokines and the adhesion molecule VCAM1, and facilitates recruitment of neutrophils and invasion of tumors (70,74)

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doi: 10.1016/j.biocel.2022.106206 159 ChunJChoiRJKhanSLeeDSKimYCNamYJet al

286 When compared to the control (water), the color changes are visible to the naked eye in phosphate buffer (pH = 7) and acetate buffer (pH = 5) (Fig