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Iron metabolism dysregulation involves labile Fe ions catalyzing lipid peroxidation via the Fenton reaction, generating hydroxyl radicals (OH) that attack polyunsaturated fatty acid (PUFA) double bonds to initiate a self-propagating lipid peroxidation chain reaction 22

Older Adults (60+ years) As we age, insulin sensitivity tends to decline, and blood sugar levels may rise slightly

Antioxidant enzymes activities and plasma levels of oxidative stress markers in B-chronic lymphocytic leukemia patients

showed that 500 M MnCl 2 exposure increased caspase 3 cleavage and reduced cell viability in PC12 cells (Yagyu et al., 2020)