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Patients with PSC have a 400-600 fold higher risk of developing CCA compared to the general population, with an annual risk between 0.5 and 1.5%

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9.1 Alternative Media and Biofilter Design While traditional BAC systems use granular activated carbon (GAC), ongoing research explores alternative media and filter configurations for greater contaminant removal or reduced maintenance: Anthracite and Sand Blends: Some systems incorporate layers of anthracite or sand to improve suspended solids removal and reduce media fouling, particularly in high-turbidity source waters