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Abbreviations ADC: Antibodydrug conjugate aGVHD: Acute graft-versus-host disease ALL: Acute lymphoblastic leukaemia AML: Acute myeloid leukaemia B-CLL: B cell chronic lymphocytic leukaemia BiTE: Bispecific T cell engagers BM: Bone marrow CAR-T: Chimeric antigen receptor T cells CD: Cluster differentiation cGvHD: Chronic graft-versus-host disease CMP: Common myeloid progenitor DLBCL: Diffuse large B cell lymphoma DLI: Donor lymphocyte infusion EBV: EpsteinBarr virus EFS: Event-free survival FDA: Food and Drug Administration GMP: Granulocytemonocyte progenitor GvHD: Graft-versus-host disease GVL: Graft versus leukaemia HLA: Human leukocyte antigen HSC: Haematopoietic stem cell HCT: Haematopoietic stem cell transplantation HSPC: Hematopoietic stem and progenitor cells MAC: Myeloablative conditioning MDS: Myelodysplastic syndrome MM: Multiple myeloma NHL: Non-Hodgkin lymphoma NK: Natural killer NRM: Non-relapse mortality OS: Overall survival PB: Peripheral blood PFS: Progression-free survival RIC: Reduced intensity conditioning SCF: Stem cell factor SCID: Severe combined immunodeficiency SOS: Sinusoidal obstructive syndrome TBI: Total body irradiation TRM: Transplant-related mortality VOD: Veno-occlusive disease WHO: World Health Organisation References Hatzimichael E, Tuthill M

52 PareynM.AlvesF.BurzaS.ChakravartyJ.AlvarJ.DiroE.et al (2025)

Moreover, there was a suggestion that the immediate exposure of BPC-157 immediately before the injury may have mitigated the damage in the murine models subjected to a force impulse, typically used to simulate TBI in research

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