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The KRAS mutations are observed in over 35% of patients of the NSCLC subtype [63, 64], together with significant Treg infiltration, particularly the KRAS G12D mutation [65]

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For ROS scavenger (Sigma-Aldrich, A9165), N-Acetyl-L-cysteine (NAC) was administered 24 hours before the induction of AKI at a dose of 200mg/kg (59, 65, 66)