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However, despite these promising metabolic benefits, SAAR has also been associated with reduced bone mineral density, weaker bones, and increased marrow fat accumulation

379 In PGC-1 knockout mouse models, DA neurons exhibit increased sensitivity to the neurotoxin MPTP, potentially due to the lack of PGC-1-mediated induction of antioxidant responses

Chelation therapy is a medical procedure that uses chelating agentssubstances that bind to heavy metals like lead, mercury, aluminum, cadmium, nickel, gadolinium, and arsenicto remove them from the bloodstream

Not commonly used for general supplementation due to cost and invasiveness