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Deficiency results in prolongation of the pro- are 100% or 1.0 unit/ml thrombin time and reduced function of vitamin K-de- pendent clotting factors Vitamin C Levels 23 mol/l indi- Plasma ascorbate cate deficiency Levels 114 nmol/ Leukocyte ascorbate 108cells (buffy coat) indi- cate deficiency Appendix III 257 Micronutrient Values Comments Urinary ascorbate Excretion of 10 mg/d indi- Insensitive index of status except in severe Ascorbate loading test cates severe deficiency deficiency Urinary ascorbate is measured after an oral dose of 0.52.0 g over 4 days

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