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Considering the volume of the mitochondrial matrix, the concentration of mitochondrial GSH (mGSH) is similar to that of cytosol (1014 m M ) (44, 48, 95)

Moreover, Mn decreased REST expression in astrocytes, while overexpression of astrocytic REST exerted protection against Mn-induced neuronal cell toxicity by regulating inflammatory cytokines and glutamate transporter GLT-1/EAAT2 in astrocytes (Pajarillo et al., 2021)

CIT, classified as a non-essential amino acid and a precursor to L-arginine, has been shown to facilitate the production of NO and promote vasodilation, consequently enhancing endothelial functionality and muscle perfusion (911)

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