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Rigorous short and long-term trials have confirmed that both drugs are more effective than placebo in reducing severity of TD and are likely better tolerated than tetrabenazine.Reference OBrien, Jimenez and Hauser 26 - Reference Fernandez, Factor and Hauser 29 , Reference Citrome 162 - Reference Lindenmayer, Verghese and Marder 165 Although both are effective compared to placebo, valbenazine has the advantage of simple titration and once-a-day dosing, whereas deutetrabenazine may allow for smaller increments of titration