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This results in less energy for the muscles and organs, leading to a general feeling of exhaustion

Accumulating evidence further demonstrates that in pSS models, reduced gut microbiome diversity and diminished production of microbiota-derived metabolites lead to decreased tolerogenic dendritic cells (DCs) and Th17/Treg imbalance, consequently promoting autoantibody accumulation and exacerbation of glandular inflammatory responses in pSS (203)

In recent decades, European port cities have emerged as key examples of waterfront transformations, implementing solutions that prioritize improved livability, water quality enhancement, and climate responsiveness (Smith and Ferrari, 2012)