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"Gut Microbiota Composition and Its Effects on Obesity and Insulin Resistance." Current Opinion in Clinical Nutrition and Metabolic Care 17.4 (2014): 312-18

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It was calculated by dividing the number of cigarettes per day by 20 (assuming one pack = 20 cigarettes) and multiplying by the number of years of smoking, assuming the average cigarettes per day applies to all previous years

Studies measuring the quantities of harmful substances actually inhaled by smokers, through the analysis of certain biomarkers contained in their urine or their breath, confirm that they are almost identical for cigarettes with or without a filter.[7] The lack of filter efficiency is not a recent discovery