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Description

Dabrafenib monotherapy induced new RAI uptake in 60% (6/10) of BRAF V600E mutant RAIR-PTC patients, while reducing serum thyroglobulin levels [113]

Proline residues interrupt alpha-helical and beta-sheet structures, producing turns and bends that may prevent proper enzyme-substrate alignment for peptide bond cleavage

Hypokalemia, and, possibly, death

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