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Sleep, in particular deep sleep, has an inhibitory influence on the hypothalamic-pituitary- adrenal (HPA) axis, whereas activation of the HPA axis or administration of glucocorticoids can lead to arousal and sleeplessness

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Several animal studies indicate that MPs reduce gut microbial diversity and shift the dominant phylum ratioparticularly elevating the Firmicutes-to-Bacteroidetes (F/B) ratiowhile depleting beneficial genera like Bifidobacterium and enriching opportunistic pathogens like Staphylococcus 31,36,77

McAndrews, KM, Paradiso, F, Stalnecker, CA, Chellakkan Selvanesan, B, Thege, F, Peng, D, Moreno Diaz, BA, Sugimoto, H, Patel, SI, Mahadevan, KK, Kirtley, ML, Wills, D, Sockwell, AM, Fonseca, AF, Liu, Y, Rajapakshe, K, Yee, N, Tran, PT, Omar, HA, Tedeschi, A, Schischlik-Siegl, F, Boghossian, AS, Rees, MG, Ronan, MM, Roth, JA, Rudolph, D, Aichinger, M, Ebner, F, Artemov, AV, Lipp, J, Pisarsky, L, Herrmann, VL, Park, JE, Rippmann, JF, Schaaf, O, Chandler, V, Williams, M, Deckard, CE, Wang, L , Der, CJ, Vellano, CP, Guerrero, PA, Heffernan, TP, Kalluri, R, Maitra, A