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Our data indicating that PrP plays a role in mediating copper toxicity in WD warrant future studies to evaluate the therapeutic potential of PrP suppression in this and other disorders of copper metabolism

Anti-factor Xa activity was determined by a validated method using the Rotachrom Heparin assay and accompanying reagents on an STA-Compact analyser (Diagnostica Stago, Inc., Parsippany, NJ, USA) [23]

The leaky gut hypothesis is often linked to the formation of opioid peptides and their subsequent passage through the blood-brain barrier, with the idea that this process may be exacerbated by heightened intestinal permeability