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E2 deficiency downregulates the Er-PGC-1-NRF1 transcriptional axis, leading to suppressed SOD2 expression and impaired clearance of mitochondrial ROS, initiating a vicious cycle of oxidative damage and mitochondrial destabilization (122)

J Pharmacol Exp Ther 187:211217 Moon KH, Abdelmegeed MA, Song BJ (2007) Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver