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Regarding PC-II, 12 traits showed positive factor loadings such as AsA, CAT, APX, TPC, POD, MDA, TSS, NRS, protease, SOD, alpha-amylase, and total flavonoids, while NRS exhibited the highest positive factor loading value (0.439), followed by TSS (0.424)

All simulations were executed using the cobrapy package in a Jupyter notebook and COBRA Toolbox version 3.0 62 in MATLAB 2020a, employing the Gurobi solver for linear programming optimizations

577 Conversely, non-pharmacological interventions, such as bladder training with scheduled voiding and pelvic floor exercises, along with intermittent catheterization, are essential to prevent urinary retention and reduce infection risks

This requires: Rapid cell division (for skin cells, fibroblasts, and endothelial cells) Adequate oxygen delivery to the wound bed Collagen synthesis and cross-linking Immune function to prevent infection Vitamin B12 contributes directly to the first two of these, and indirectly to the others