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By age 60, plasma concentrations drop to approximately 80 ng/mL

This is your sterile field

Some of these may be borne out as the trials read out, and the fair summary for now is that promotion has run ahead of the human evidence

Continuation of semaglutide resulted in a further 7.9% reduction in body weight from their week 20 weight, whereas the placebo group regained 6.9% [92]