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This change results in a missense change, an alanine to valine substitution, at codon 222

Animal experiment All procedures for animal experiments in this study were authorized by the Institutional Animal Care and Use Committee (IACUC) of Seoul National University (Approval Number: 220038-S1A0) and complied with the guidelines for the care and use of laboratory animals

In todays population, heavy metal toxicity is ubiquitous, along with exposure to many other endogenous neurotoxic chemicals, which means that inevitably the biochemical individuality to deal with these toxins may be the major determinate of disease

Cell Mol Life Sci