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Studies in a humanized APOE3-Ch knock-in mouse model, crossed with an A plaque-depositing model, demonstrated that ApoE3-Ch alters microglial responses and suppresses A -induced tau seeding and spreading (Chen et al., 2024)

Cell viability (using MTT assay), cell apoptosis (via flow cytometry), the level of malondialdehyde (MDA), and the expression levels of hsa-miR-16-5p, hsa-miR- 34a-5p, B-cell lymphoma 2 (BCL-2), cyclin D1 (CCND1), and sirtuin 1 (SIRT1) were measured (via real-time PCR)

A deficiency in vitamin B12 can potentially lead to megaloblastic anemia, a medical condition characterized by a reduced red blood cell count and the presence of abnormally large red blood cells

New insight into neurological degeneration: inflammatory cytokines and bloodbrain barrier