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Uptake and metabolization of serotonin by granulosa cells form a functional barrier in the mouse ovary

Front Cardiovasc

The gross pathology may resemble that of NSAID- or other ingestion-induced gastritis, except that the location of injury is different

Such haptenated proteins can disrupt protein folding or function and lead to direct toxicity, or can be recognized as non-self leading to immune-mediated toxicity (Tafazoli and OBrien, 2009