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GHK-Cu also stimulates both collagen synthesis and matrix metalloproteinases that break collagen down, so unbalanced or excessive use could in principle disrupt extracellular-matrix homeostasis

Lipopolysaccharide ( Escherichia coli O111:B4), thioclycollate and 2,7-dichlorofluorescin-diacetate (DCFDA) were purchased from Sigma (MO, USA)

Fumarate Fumarate is another example of an oncometabolite produced by the action of fumarate hydratase on succinate

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