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Here, we show that the overexpression of HRASV12 or cyclin E1 induces R-loop formation specifically in the S-phase of the cell cycle and that R-loops are the primary cause of replication fork reversal and chromosome mis-segregation induced by these oncogenes

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The effect of selenium on GPX activity There are approximate 25 selenoproteins in humans, and selenium is an essential cofactor for these proteins, including the glutathione peroxidases

Molecules may cross transcellularly in a number of mechanisms: 1) passive transport, as is the case for small compounds that may diffuse across the epithelial cell membrane