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As a result of the discovery, the British sailors became known as Limeys because they would drink lime juice to prevent the development of the disease4

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Important aspects like fibroblast heterogeneity, functional specialization and cellular plasticity are also discussed as well as the implications that these aspects may have in disease and in the design of novel therapeutics

As understanding of PCOS evolves, IR is increasingly recognized as a key factor in the pathogenesis of the disorder, resulting in the widespread utilization of metformin, a medication that enhances insulin sensitivity, for the management of PCOS