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Moreover, the concurrent increase in HK2 expression, without a corresponding rise in gluconeogenic enzymes (G6PC and PCK1), suggests preferential glycolytic rather than gluconeogenic metabolism in the intestine after metformin administration

Future trials should examine both induction and maintenance therapy applications, biomarker responses, and endoscopic healing outcomes to establish clinical utility

While protein glycosylation is paramount for enveloped viruses 30 , we did not include glycosylated proteins in the viral biomass reaction due to a lack of information on virus-specific protein glycosylation

For a visual walk-through, see the reconstitution guide