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Studies have shown that risk-adapted preemptive tocilizumab effectively prevents grade 4 CRS following CTL019 treatment for pediatric B-cell acute lymphoblastic leukemia, without adversely affecting the antitumor efficacy or safety of CTL019

Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer

This matters because it shows how researchers expand the endpoint set depending on population and protocol: weight endpoints remain central, while glycaemic endpoints are included when the population and study design require them

As researchers focus more on regenerative medicine and aging, what theyve found is that NAD+ is a driving force in the aging process