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( 21 H 20 O 6 ( Curcumin has a melting point of 183C and exhibits diketone/keto-enol tautomerism due to its -diketone moiety ( The lipophilic nature of curcumin is collectively attributed to its nonpolar methyl groups, aromatic rings, and aliphatic bridge ( P value, which decreases (from 3.2) with increased polarity upon hydroxyl group deprotonation, enhancing its water solubility and facilitating its elimination ( Manolova et al

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6a, Supplementary Data 9)