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These agents represent diverse approaches to aging intervention, from FDA-approved therapeutics to investigational compounds, each targeting distinct but interconnected aging pathways (Table 1)

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Notably, elevated levels of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], a subclass of eicosanoids, activate the intracellular cation channel transient receptor potential vanilloid one and mediate endothelial dysfunction in DM (Otto et al., 2020)

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