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The association between mitochondrial activity and low sensitivity to anthracyclines, Ara-C, and Venetoclax has been documented in cell lines and primary leukemia cells and confirmed using in vivo models (Figure 2)

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Conclusions Based on the literature published, the MoAs of both LDX and MPH (current first-line pharmacological treatments) have an effect in the network of the specific molecules involved in the described pathophysiological motives of ADHD