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In contrast to the transport processes, where metabolite transport against a gradient proceeds by secondary active transport, the uptake of glutathione conjugates into the vacuole proceeds by an ATP-driven primary active transport (Fig

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The GSDMD pores in the membrane will collapse ion gradients and lead to an influx of water, ultimately resulting in ninjurin 1 (NINJ1)-dependent cell membrane rupture and the release of DAMPs [122]

For example, people with medical conditions associated with fat malabsorption, including cystic fibrosis and Crohns disease, are at an increased risk