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Chronic inflammation causes the reduction of Phe conversion to Tyr and, consequently, higher Phe levels could be found in tissues with chronic inflammation 18

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PLoS ONE 3:e1703 Iyer J, Singh MD, Jensen M, Patel P, Pizzo L, Huber E, Koerselman H, Weiner AT, Lepanto P, Vadodaria K (2018) Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11

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