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The Health Equity Benchmark Adjustment (HEBA) we are finalizing with modifications, described in section III.G.7.b of this final rule, will add a third avenue for ACOs to receive a positive adjustment to their historical benchmark, and will be most impactful for new ACOs serving medically complex, high-cost populations in underserved communities

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Deficiency of tetrahydrobiopterin, an essential cofactor for eNOS, has been shown to promote eNOS unpairing, which attenuates NO production and tends to enhance ROS production [75]