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The multimodal therapy approach described in this article aims to control each of the pain mechanisms identified

Introduction Asthma, a chronic inflammatory disease of the lung, affects up to 300 million people worldwide and remains a major cause of morbidity and mortality ( Despite advances in understanding the cellular drivers of asthma, several fundamental features of the disease remain poorly explained

This mechanism constructs a pathological intracellular positive feedback loop, forcing macrophages to maintain a high-glycolysis, high-inflammation metabolic state (Warburg effect), which in turn leads to the massive release of inflammatory factors and exacerbates lung tissue injury

It has been observed that the interference in these pathways in complex ways has the greatest impact on disease development [12], apoptosis, cytokine production and inflammatory responses, and proteasome dysfunction