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This, along with the upregulation of multiple mitochondrial genes involved in heme synthesis, OXPHOS assembly and mitochondrial fusion, might be an effort to compensate for the mitochondrial defect caused by the cIII disruption

These include transaminases, glutamate dehydrogenase and deaminases

Additionally, primary hepatocytes were obtained from a single donor, so future studies will investigate inter-individual variation in ITZ toxicity in vitro and in vivo

Some reports have also indicated an increase of Streptococcus spp., a pathogenic bacterium which causes increased levels of IL-6, and mucin degraders such as Ruminococcus spp