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11 Cardiac arrhythmia has also been reported and is associated with a cytokine storm-triggered systemic hyperinflammatory state and immune response that may cause injury to cardiac monocytes, resulting in myocardial dysfunction and the ensuing development of arrhythmia

Cysteine availability is often the rate limiter for glutathione synthesis, and thus supplementing with NAC increases net glutathione levels, which is useful in disease states characterized by ischemia, increased oxidative stress, and reduced available glutathione [210, 211]