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This modulation decreases the metabolism of the cardiovascular risk factor phenylalanine, ultimately reducing myocardial collagen deposition, lowering the cardiac weight index, slowing the progression of myocardial fiber thickening and necrosis, and preventing and ameliorating ISO-induced myocardial fibrosis ( 3.3 Antagonism targeting ion channel disorders Oxidative stress and inflammatory processes accelerate the development of atrial fibrosis, leading to increased collagen deposition and structural remodeling of the atria

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NF-B, the core transcription factor in the NF-B signaling pathway, is a dimer family formed by p50/p105/NF-B1, p52/p100/NF-B2, c-Rel, p65/RelA and RelB (44)

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Therefore, compound 968 may provide new therapeutic strategies for the treatment of different types of cancers

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