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As a result, a hypertonic solution obtained by adding 100 mOsm.l 1 of mannitol to isotonic PBS medium (Mannitol, osmolarity increased to ~400 mOsm.l 1 without modification of ion concentrations) greatly decreased MSU and CPP crystal-induced IL-1 production (200 g/ml, 3 h, Fig

The pre- and post-treatment subscores in five different domains are outlined in Table 4

Sativex produced no statistically significant improvement in either the mean daily pain scores (primary outcome measure) or quality-of-life assessments (secondary outcome measures)