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Studies demonstrated that berberine contributed to AMPK signaling pathway activation and participate in anti-neuroinflammation

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Complex I dysfunction results in substantially reduced ATP production, creating an energy deficit that directly compromises sperm motility and cellular function ( 3.4 Molecular pathway interaction networks The reproductive toxicity induced by EEDs results from complex crosstalk among oxidative stress responses, metabolic disruption, and immune system activation rather than isolated pathway effects

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