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Strenuous Exercise: Vigorous physical activity can temporarily affect hydration levels, electrolytes, and certain enzyme markers

The 2016 Zubair trial with 50 Pakistani women represents the only placebo-controlled study, showing 37.5% completion rate versus 18.7% placebo (p=0.054), which failed to reach statistical significance

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In part B of the study, which was open label, patients were assigned to receive a single IV infusion of pegadricase alone (0.4 mg/kg) alone, or SEL-212 (0.03, 0.1, 0.15, or 0.3 mg/kg ImmTOR combined with 0.4 mg/kg pegadricase