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FIGURE 4 5.5 Challenges and prospects of antioxidant therapy Antioxidant therapy in the context of CNS diseases is confronted with numerous challenges, such as the high incidence of failed clinical trials, the intricate role of oxidative stress in disease pathology, the impediment posed by the blood-brain barrier to drug permeation, and the specific needs for activators of antioxidant enzymes

Observations on the antidepressant effects of paeoniflorin in a model of drug-induced depression

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Ashley D, Hernandez J, Cao R, To K, Yegiazaryan A, Abrahem R, Nguyen T, Owens J, Lambros M, Subbian S, et al