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The pathway is sometimes referred to as a cycle, but according to its classical representation, it is a linear sequence that links reduction of H 2 O 2 , catalysed by APX, to oxidation of NADH or NADPH, catalysed by MDHAR and GR (Fig

It is characterised by rigidity, slowness and tremor, and causes disabling symptoms including dementia, depression and hallucinations

Both A and B contain 10 mM ammonium acetate (negative ion mode) or 10 mM ammonium formate (positive ion mode)

The platform is based on drying plant materials, extraction of polyphenols through membrane technologies with water, and, when necessary, the concentration of the final fractions under vacuum evaporation