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Mechanisms of induction of regulatory B cells in the tumor microenvironment and their contribution to immunosuppression and pro-tumor responses

Firstly, copper activates the autophagy process by upregulating the expression of autophagy-related genes such as Beclin1, ATG5, LC3, mTOR, and Dynein, 246,247 while also activating autophagic kinases ULK1 and ULK2