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Regular alcohol intake can lead to a reduction in the absorption and storage of various B vitamins , particularly Vitamin B1 (thiamine)

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79, Supplementary Table 1 and 2, and Supplementary Data 1) demonstrate that rearrangement of surrounding residues could allow BV to bind with Ab Pcob in certain conformations, where hydrophobic interactions with residues in the binding pocket (e.g., Leu252, Trp289, Leu294, Arg297, Val299 and Val303) contribute to retain BV in the correct orientation (Fig