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This variability likely reflects differences in underlying pigmentation mechanisms, treatment concentrations, vehicle formulations, and patient populations

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Clinical studies have confirmed that glutathione infusion, prior to the introduction of anticancer chemotherapy in patients with ovarian carcinoma, gastric carcinoma, and colorectal cancer, provides effective protection against renal failure and neurotoxicity caused by the use of cisplatin and oxaliplatin, which allows, if necessary, to achieve higher cumulative doses of the anticancer agent