nadph dependent glutathione reductase - an overview Thioredoxin Glutathione Reductase from Schistosoma

10.1172/jci.insight.85717 JCI Insight

Inhibition of activities of the cystine/glutamate transporter system decreases cystine absorption, thereby reducing GSH synthesis, followed by decreased membrane lipid repair enzyme GPX4 activities, reduced antioxidant capacities and ferroptosis ( Chemotherapy is the preferred therapeutic option for cancer, however, long-term chemotherapy leads to increased tumor cell resistance ( 2 Ferroptosis mechanisms Studies are increasingly aimed at elucidating the mechanisms of ferroptosis

10.1016/j.freeradbiomed.2010.12.029 55

These findings suggest that MSU38225 could serve as an adjuvant therapy, enhancing the sensitivity of lung cancer patients to chemotherapy [99]